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OCR: ol are The major hormones under GnRH con mulating luteinising hormone (LH) and follicle-st pituitary hormone (FSH) (Fig. 11.4). GnRH acts or stimulate gonadotrophs via cell-surface receptors ependent, the release of LH and FSH by a calcium- lycerols CAMP-independent, mechanism. Diacyl 1. In may amplify the calcium-mediated sign i effect on addition, GnRH probably has a long-term LH and FSH synthesis. The episodic secretion of GnRH into the h, in hypophysial portal system results, in tur e secretoryepisodic secretion of LH. In adult men, t pulses of LH occur at a frequency of eigh secretion fourteen per twenty-four hours, Pulsatil itude. of FSH also occurs but with a lower amp